AlzMap
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Overview
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TSNE
Metadata
WGCNA modules
Celltype signatures
Gene Ontology
Marioni GWAS sets
Gene
Quadrant Plot
Gene Ontology Clusters
Gene Ontology
WGCNA Co-expression clusters
Celltypes
GWAS genes
Region plot
Gene Expression
Geneset Expression
Differential Gene Expression
Differential Geneset Expression
IHC scores
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Region data scatter plot
Scatter plot allowing the comparison of a variety of region statistics
Region Stats Scatter plot
Plot Settings
X axis
Category
geneset / WGCNA co-expression modules
geneset / GO categories
geneset / Marioni GWAS genes
geneset / Celltypes
Spot score
Statistic
Mean Expression
Diff. Expression Genotype
Diff. Expression ABeta
Gene
mean geneset / co-expression modules
WGCNA black
WGCNA blue
WGCNA brown
WGCNA green
WGCNA greenyellow
WGCNA magenta
WGCNA pink
WGCNA PIGS (purple)
WGCNA OLIG (red)
WGCNA tan
WGCNA turquoise
WGCNA yellow
mean genset / GO categories
Go ribosomal small subunit assembly (go_0000028)
Go g protein-coupled receptor binding (go_0001664)
Go lytic vacuole (go_0000323)
Go negative regulation of transcription by rna polymerase ii (go_0000122)
Go proteasome complex (go_0000502)
Go cell morphogenesis (go_0000902)
Go rna polymerase ii regulatory region sequence-specific dna binding (go_0000977)
Go transcription regulatory region sequence-specific dna binding (go_0000976)
Go antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii (go_0002504)
Go rna polymerase ii proximal promoter sequence-specific dna binding (go_0000978)
Go dna-binding transcription factor activity, rna polymerase ii-specific (go_0000981)
Go proximal promoter sequence-specific dna binding (go_0000987)
Go rna polymerase ii regulatory region dna binding (go_0001012)
Go regulatory region nucleic acid binding (go_0001067)
Go <unknown category> (go_0001077)
Go dna-binding transcription activator activity, rna polymerase ii-specific (go_0001228)
Go regulation of neurotransmitter levels (go_0001505)
Go microglial cell activation (go_0001774)
Go cell activation (go_0001775)
Go regulation of cytokine production (go_0001817)
Go negative regulation of cytokine production (go_0001818)
Go positive regulation of cytokine production (go_0001819)
Go positive regulation of protein phosphorylation (go_0001934)
Go cytoplasmic translation (go_0002181)
Go response to molecule of bacterial origin (go_0002237)
Go adaptive immune response (go_0002250)
Go immune effector process (go_0002252)
Go activation of immune response (go_0002253)
Go myeloid leukocyte activation (go_0002274)
Go leukocyte mediated immunity (go_0002443)
Go lymphocyte mediated immunity (go_0002449)
Go antigen processing and presentation of exogenous peptide antigen (go_0002478)
Go adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002460)
Go antigen processing and presentation of peptide antigen via mhc class ii (go_0002495)
Go regulation of leukocyte migration (go_0002685)
Go leukocyte differentiation (go_0002521)
Go monovalent inorganic cation transmembrane transporter activity (go_0015077)
Go regulation of antigen processing and presentation (go_0002577)
Go positive regulation of antigen processing and presentation (go_0002579)
Go negative regulation of immune system process (go_0002683)
Go positive regulation of immune system process (go_0002684)
Go positive regulation of leukocyte migration (go_0002687)
Go regulation of leukocyte activation (go_0002694)
Go negative regulation of leukocyte activation (go_0002695)
Go positive regulation of leukocyte activation (go_0002696)
Go regulation of immune effector process (go_0002697)
Go positive regulation of immune effector process (go_0002699)
Go regulation of leukocyte mediated immunity (go_0002703)
Go regulation of adaptive immune response (go_0002819)
Go positive regulation of adaptive immune response (go_0002821)
Go regulation of b cell apoptotic process (go_0002902)
Go regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002822)
Go cilium movement (go_0003341)
Go developmental process involved in reproduction (go_0003006)
Go chromatin binding (go_0003682)
Go double-stranded dna binding (go_0003690)
Go dna-binding transcription factor activity (go_0003700)
Go transcription coregulator activity (go_0003712)
Go structural constituent of ribosome (go_0003735)
Go structural constituent of ribosome (go_0003735)
Go motor activity (go_0003774)
Go cytochrome-c oxidase activity (go_0004129)
Go cysteine-type endopeptidase activity (go_0004197)
Go hydrolase activity, hydrolyzing o-glycosyl compounds (go_0004553)
Go hormone activity (go_0005179)
Go neuropeptide hormone activity (go_0005184)
Go neuropeptide hormone activity (go_0005184)
Go structural molecule activity (go_0005198)
Go extracellular matrix structural constituent (go_0005201)
Go ion channel activity (go_0005216)
Go cation channel activity (go_0005261)
Go calcium ion binding (go_0005509)
Go glycosaminoglycan binding (go_0005539)
Go mitochondrial outer membrane (go_0005741)
Go mitochondrial inner membrane (go_0005743)
Go mitochondrial respiratory chain complex i (go_0005747)
Go lysosome (go_0005764)
Go lysosomal membrane (go_0005765)
Go endosome (go_0005768)
Go early endosome (go_0005769)
Go late endosome (go_0005770)
Go vacuole (go_0005773)
Go vacuolar membrane (go_0005774)
Go endoplasmic reticulum membrane (go_0005789)
Go ribosome (go_0005840)
Go cell-cell junction (go_0005911)
Go carbohydrate metabolic process (go_0005975)
Go alcohol metabolic process (go_0006066)
Go organic acid metabolic process (go_0006082)
Go translation (go_0006412)
Go protein folding (go_0006457)
Go ubiquitin-dependent protein catabolic process (go_0006511)
Go peptide metabolic process (go_0006518)
Go membrane lipid metabolic process (go_0006643)
Go cellular amino acid metabolic process (go_0006520)
Go phospholipid metabolic process (go_0006644)
Go glycerophospholipid metabolic process (go_0006650)
Go glycolipid metabolic process (go_0006664)
Go sphingolipid metabolic process (go_0006665)
Go ceramide metabolic process (go_0006672)
Go steroid biosynthetic process (go_0006694)
Go cholesterol biosynthetic process (go_0006695)
Go coenzyme metabolic process (go_0006732)
Go nucleoside phosphate metabolic process (go_0006753)
Go cation transport (go_0006812)
Go neurotransmitter transport (go_0006836)
Go mitochondrial transport (go_0006839)
Go amino acid transport (go_0006865)
Go intracellular protein transport (go_0006886)
Go endocytosis (go_0006897)
Go autophagy (go_0006914)
Go chemotaxis (go_0006935)
Go defense response (go_0006952)
Go inflammatory response (go_0006954)
Go immune response (go_0006955)
Go immune response (go_0006955)
Go mitochondrion organization (go_0007005)
Go cytoskeleton organization (go_0007010)
Go microtubule-based process (go_0007017)
Go vacuole organization (go_0007033)
Go cell adhesion (go_0007155)
Go leukocyte cell-cell adhesion (go_0007159)
Go heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (go_0007157)
Go negative regulation of cell adhesion (go_0007162)
Go enzyme linked receptor protein signaling pathway (go_0007167)
Go neuropeptide signaling pathway (go_0007218)
Go neuropeptide signaling pathway (go_0007218)
Go small gtpase mediated signal transduction (go_0007264)
Go ensheathment of neurons (go_0007272)
Go pattern specification process (go_0007389)
Go nervous system development (go_0007399)
Go axon guidance (go_0007411)
Go heart development (go_0007507)
Go behavior (go_0007610)
Go learning or memory (go_0007611)
Go memory (go_0007613)
Go locomotory behavior (go_0007626)
Go feeding behavior (go_0007631)
Go chemokine activity (go_0008009)
Go beta-catenin binding (go_0008013)
Go synaptic vesicle (go_0008021)
Go enzyme activator activity (go_0008047)
Go cytoskeletal protein binding (go_0008092)
Go steroid metabolic process (go_0008202)
Go cholesterol metabolic process (go_0008203)
Go regulation of blood pressure (go_0008217)
Go cell population proliferation (go_0008283)
Go positive regulation of cell population proliferation (go_0008284)
Go negative regulation of cell population proliferation (go_0008285)
Go lipid binding (go_0008289)
Go cation transmembrane transporter activity (go_0008324)
Go regulation of cell shape (go_0008360)
Go axon ensheathment (go_0008366)
Go atp-dependent microtubule motor activity, minus-end-directed (go_0008569)
Go lipid biosynthetic process (go_0008610)
Go phospholipid biosynthetic process (go_0008654)
Go macromolecule catabolic process (go_0009057)
Go macromolecule biosynthetic process (go_0009059)
Go nucleotide metabolic process (go_0009117)
Go nucleotide biosynthetic process (go_0009165)
Go ribonucleotide biosynthetic process (go_0009260)
Go response to biotic stimulus (go_0009607)
Go response to virus (go_0009615)
Go response to bacterium (go_0009617)
Go axis specification (go_0009798)
Go animal organ morphogenesis (go_0009887)
Go tissue development (go_0009888)
Go regulation of catabolic process (go_0009894)
Go positive regulation of catabolic process (go_0009896)
Go external side of plasma membrane (go_0009897)
Go cell surface (go_0009986)
Go proteasomal protein catabolic process (go_0010498)
Go regulation of autophagy (go_0010506)
Go regulation of hormone levels (go_0010817)
Go positive regulation of cell development (go_0010720)
Go regulation of cell morphogenesis involved in differentiation (go_0010769)
Go positive regulation of cell death (go_0010942)
Go regulation of metal ion transport (go_0010959)
Go regulation of neuron projection development (go_0010975)
Go postsynaptic density (go_0014069)
Go ion transmembrane transporter activity (go_0015075)
Go proteasome-mediated ubiquitin-dependent protein catabolic process (go_0043161)
Go secondary active transmembrane transporter activity (go_0015291)
Go inorganic molecular entity transmembrane transporter activity (go_0015318)
Go tubulin binding (go_0015631)
Go large ribosomal subunit (go_0015934)
Go small ribosomal subunit (go_0015935)
Go immunoglobulin mediated immune response (go_0016064)
Go sterol metabolic process (go_0016125)
Go sterol biosynthetic process (go_0016126)
Go vesicle-mediated transport (go_0016192)
Go positive regulation of macroautophagy (go_0016239)
Go regulation of macroautophagy (go_0016241)
Go cell migration (go_0016477)
Go oxidoreductase activity (go_0016491)
Go oxidoreductase activity, acting on nad(p)h (go_0016651)
Go heterocycle biosynthetic process (go_0018130)
Go cytokine-mediated signaling pathway (go_0019221)
Go aromatic compound biosynthetic process (go_0019438)
Go organophosphate metabolic process (go_0019637)
Go ribose phosphate metabolic process (go_0019693)
Go b cell mediated immunity (go_0019724)
Go cellular homeostasis (go_0019725)
Go carboxylic acid metabolic process (go_0019752)
Go rrna binding (go_0019843)
Go organelle inner membrane (go_0019866)
Go outer membrane (go_0019867)
Go antigen processing and presentation (go_0019882)
Go antigen processing and presentation of exogenous antigen (go_0019884)
Go kinase binding (go_0019900)
Go central nervous system myelination (go_0022010)
Go antigen processing and presentation of exogenous peptide antigen via mhc class ii (go_0019886)
Go structural constituent of myelin sheath (go_0019911)
Go modification-dependent protein catabolic process (go_0019941)
Go cell cycle process (go_0022402)
Go regulation of cell-cell adhesion (go_0022407)
Go positive regulation of cell-cell adhesion (go_0022409)
Go cellular component disassembly (go_0022411)
Go regulation of cell morphogenesis (go_0022604)
Go biological adhesion (go_0022610)
Go cytosolic large ribosomal subunit (go_0022625)
Go cytosolic small ribosomal subunit (go_0022627)
Go active transmembrane transporter activity (go_0022804)
Go <unknown category> (go_0022838)
Go transmembrane transporter activity (go_0022857)
Go inorganic cation transmembrane transporter activity (go_0022890)
Go regulation of transmembrane transporter activity (go_0022898)
Go signaling (go_0023052)
Go cell projection organization (go_0030030)
Go regulation of endocytosis (go_0030100)
Go transport vesicle (go_0030133)
Go regulation of cell adhesion (go_0030155)
Go regulation of proteolysis (go_0030162)
Go protein catabolic process (go_0030163)
Go integral component of endoplasmic reticulum membrane (go_0030176)
Go neuron differentiation (go_0030182)
Go carbohydrate binding (go_0030246)
Go regulation of cell migration (go_0030334)
Go positive regulation of cell migration (go_0030335)
Go positive regulation of cell migration (go_0030335)
Go dendrite (go_0030425)
Go ubiquitin-dependent erad pathway (go_0030433)
Go receptor regulator activity (go_0030545)
Go neutrophil chemotaxis (go_0030593)
Go neutrophil chemotaxis (go_0030593)
Go leukocyte chemotaxis (go_0030595)
Go regulation of b cell proliferation (go_0030888)
Go nadh dehydrogenase complex (go_0030964)
Go secretion by cell (go_0032940)
Go extracellular matrix (go_0031012)
Go neuron projection development (go_0031175)
Go intrinsic component of endoplasmic reticulum membrane (go_0031227)
Go intrinsic component of organelle membrane (go_0031300)
Go regulation of cellular catabolic process (go_0031329)
Go regulation of cell projection organization (go_0031344)
Go positive regulation of cell projection organization (go_0031346)
Go regulation of defense response (go_0031347)
Go positive regulation of defense response (go_0031349)
Go regulation of neurological system process (go_0031644)
Go haptoglobin-hemoglobin complex (go_0031838)
Go mitochondrial membrane (go_0031966)
Go organelle outer membrane (go_0031968)
Go membrane-enclosed lumen (go_0031974)
Go regulation of response to external stimulus (go_0032101)
Go negative regulation of response to external stimulus (go_0032102)
Go positive regulation of response to external stimulus (go_0032103)
Go axon ensheathment in central nervous system (go_0032291)
Go regulation of intracellular transport (go_0032386)
Go regulation of transporter activity (go_0032409)
Go regulation of ion transmembrane transporter activity (go_0032412)
Go regulation of interleukin-6 production (go_0032675)
Go regulation of tumor necrosis factor production (go_0032680)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go regulation of protein localization (go_0032880)
Go regulation of mononuclear cell proliferation (go_0032944)
Go cellular component morphogenesis (go_0032989)
Go amide binding (go_0033218)
Go axon part (go_0033267)
Go positive regulation of kinase activity (go_0033674)
Go response to lipid (go_0033993)
Go response to cytokine (go_0034097)
Go ion transmembrane transport (go_0034220)
Go response to interferon-gamma (go_0034341)
Go cellular protein localization (go_0034613)
Go cellular protein-containing complex assembly (go_0034622)
Go cellular macromolecule biosynthetic process (go_0034645)
Go ncrna metabolic process (go_0034660)
Go ion channel complex (go_0034702)
Go cation channel complex (go_0034703)
Go regulation of transmembrane transport (go_0034762)
Go regulation of ion transmembrane transport (go_0034765)
Go response to endoplasmic reticulum stress (go_0034976)
Go non-canonical wnt signaling pathway (go_0035567)
Go erad pathway (go_0036503)
Go locomotion (go_0040011)
Go regulation of locomotion (go_0040012)
Go positive regulation of locomotion (go_0040017)
Go regulation of t cell proliferation (go_0042129)
Go regulation of protein catabolic process (go_0042176)
Go ribosomal small subunit biogenesis (go_0042274)
Go peptide binding (go_0042277)
Go positive regulation of phosphorylation (go_0042327)
Go taxis (go_0042330)
Go regulation of membrane potential (go_0042391)
Go myelination (go_0042552)
Go mhc protein complex (go_0042611)
Go antigen processing and presentation of exogenous peptide antigen via mhc class i (go_0042590)
Go mhc class ii protein complex (go_0042613)
Go mhc class ii protein complex (go_0042613)
Go polysomal ribosome (go_0042788)
Go protein homodimerization activity (go_0042803)
Go neuronal cell body (go_0043025)
Go peptide biosynthetic process (go_0043043)
Go response to external biotic stimulus (go_0043207)
Go dendritic spine (go_0043197)
Go positive regulation of mapk cascade (go_0043410)
Go myelin sheath (go_0043209)
Go myelin sheath (go_0043209)
Go organelle lumen (go_0043233)
Go receptor complex (go_0043235)
Go regulation of ion transport (go_0043269)
Go regulation of protein complex assembly (go_0043254)
Go regulation of mapk cascade (go_0043408)
Go positive regulation of endocytosis (go_0045807)
Go oxoacid metabolic process (go_0043436)
Go positive regulation of cellular component biogenesis (go_0044089)
Go cellular amide metabolic process (go_0043603)
Go amide biosynthetic process (go_0043604)
Go regulation of multi-organism process (go_0043900)
Go modification-dependent macromolecule catabolic process (go_0043632)
Go regulation of system process (go_0044057)
Go regulation of cellular component biogenesis (go_0044087)
Go antigen processing and presentation of peptide antigen (go_0048002)
Go transcription regulatory region dna binding (go_0044212)
Go cellular lipid metabolic process (go_0044255)
Go cellular macromolecule catabolic process (go_0044265)
Go small molecule biosynthetic process (go_0044283)
Go cell body (go_0044297)
Go neuron spine (go_0044309)
Go ubiquitin-like protein ligase binding (go_0044389)
Go ribosomal subunit (go_0044391)
Go mitochondrial part (go_0044429)
Go golgi apparatus part (go_0044431)
Go endoplasmic reticulum part (go_0044432)
Go cytoplasmic vesicle part (go_0044433)
Go vacuolar part (go_0044437)
Go endosomal part (go_0044440)
Go ciliary part (go_0044441)
Go cytosolic part (go_0044445)
Go axoneme part (go_0044447)
Go mitochondrial membrane part (go_0044455)
Go innate immune response (go_0045087)
Go membrane raft (go_0045121)
Go postsynaptic membrane (go_0045211)
Go respiratory chain complex i (go_0045271)
Go leukocyte activation (go_0045321)
Go dynein light chain binding (go_0045503)
Go dynein intermediate chain binding (go_0045505)
Go negative regulation of cell differentiation (go_0045596)
Go regulation of myeloid cell differentiation (go_0045637)
Go regulation of neuron differentiation (go_0045664)
Go alcohol biosynthetic process (go_0046165)
Go ribose phosphate biosynthetic process (go_0046390)
Go glycerolipid metabolic process (go_0046486)
Go phosphatidylinositol metabolic process (go_0046488)
Go metal ion transmembrane transporter activity (go_0046873)
Go protein heterodimerization activity (go_0046982)
Go perinuclear region of cytoplasm (go_0048471)
Go cofactor binding (go_0048037)
Go golgi vesicle transport (go_0048193)
Go lymphocyte chemotaxis (go_0048247)
Go cell development (go_0048468)
Go neuron projection morphogenesis (go_0048812)
Go rhythmic process (go_0048511)
Go embryonic morphogenesis (go_0048598)
Go neuron development (go_0048666)
Go multicellular organismal reproductive process (go_0048609)
Go anatomical structure formation involved in morphogenesis (go_0048646)
Go regulation of smooth muscle cell proliferation (go_0048660)
Go tissue morphogenesis (go_0048729)
Go system development (go_0048731)
Go positive regulation of cellular component movement (go_0051272)
Go cell projection morphogenesis (go_0048858)
Go cell motility (go_0048870)
Go coenzyme binding (go_0050662)
Go regulation of lymphocyte proliferation (go_0050670)
Go regulation of epithelial cell proliferation (go_0050678)
Go regulation of inflammatory response (go_0050727)
Go regulation of neurogenesis (go_0050767)
Go positive regulation of neurogenesis (go_0050769)
Go regulation of immune response (go_0050776)
Go positive regulation of immune response (go_0050778)
Go ion homeostasis (go_0050801)
Go modulation of chemical synaptic transmission (go_0050804)
Go regulation of synapse organization (go_0050807)
Go cell adhesion molecule binding (go_0050839)
Go regulation of t cell activation (go_0050863)
Go regulation of cell activation (go_0050865)
Go cognition (go_0050890)
Go negative regulation of cell activation (go_0050866)
Go positive regulation of cell activation (go_0050867)
Go positive regulation of t cell activation (go_0050870)
Go leukocyte migration (go_0050900)
Go positive regulation of chemotaxis (go_0050921)
Go actin filament binding (go_0051015)
Go regulation of secretion (go_0051046)
Go cofactor metabolic process (go_0051186)
Go regulation of lymphocyte activation (go_0051249)
Go positive regulation of lymphocyte activation (go_0051251)
Go regulation of cellular component movement (go_0051270)
Go positive regulation of nervous system development (go_0051962)
Go regulation of hydrolase activity (go_0051336)
Go positive regulation of hydrolase activity (go_0051345)
Go positive regulation of transferase activity (go_0051347)
Go defense response to virus (go_0051607)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go multi-organism process (go_0051704)
Go response to other organism (go_0051707)
Go regulation of calcium ion transport (go_0051924)
Go dynein light intermediate chain binding (go_0051959)
Go oxidation-reduction process (go_0055114)
Go transmembrane transport (go_0055085)
Go regulation of plasma membrane bounded cell projection organization (go_0120035)
Go nucleobase-containing small molecule metabolic process (go_0055086)
Go cell chemotaxis (go_0060326)
Go regulation of cellular localization (go_0060341)
Go epithelium development (go_0060429)
Go nucleoside-triphosphatase regulator activity (go_0060589)
Go regulation of vesicle-mediated transport (go_0060627)
Go membrane organization (go_0061024)
Go process utilizing autophagic mechanism (go_0061919)
Go collagen-containing extracellular matrix (go_0062023)
Go intracellular organelle lumen (go_0070013)
Go large ribosomal subunit rrna binding (go_0070180)
Go regulation of establishment of protein localization (go_0070201)
Go regulation of erk1 and erk2 cascade (go_0070372)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go exocytic vesicle (go_0070382)
Go respirasome (go_0070469)
Go protein localization to mitochondrion (go_0070585)
Go regulation of leukocyte proliferation (go_0070663)
Go positive regulation of leukocyte proliferation (go_0070665)
Go cellular macromolecule localization (go_0070727)
Go cellular response to biotic stimulus (go_0071216)
Go cellular response to molecule of bacterial origin (go_0071219)
Go cellular response to cytokine stimulus (go_0071345)
Go cellular response to interferon-gamma (go_0071346)
Go granulocyte chemotaxis (go_0071621)
Go ribonucleoprotein complex subunit organization (go_0071826)
Go neuropeptide receptor binding (go_0071855)
Go cellular divalent inorganic cation homeostasis (go_0072503)
Go divalent inorganic cation homeostasis (go_0072507)
Go establishment of protein localization to organelle (go_0072594)
Go establishment of protein localization to mitochondrion (go_0072655)
Go lymphocyte migration (go_0072676)
Go organophosphate biosynthetic process (go_0090407)
Go synaptic membrane (go_0097060)
Go neuron projection guidance (go_0097485)
Go myeloid leukocyte migration (go_0097529)
Go granulocyte migration (go_0097530)
Go defense response to other organism (go_0098542)
Go side of membrane (go_0098552)
Go bounding membrane of organelle (go_0098588)
Go membrane region (go_0098589)
Go cell-cell adhesion (go_0098609)
Go anion transmembrane transport (go_0098656)
Go import into cell (go_0098657)
Go cell-cell adhesion via plasma-membrane adhesion molecules (go_0098742)
Go presynapse (go_0098793)
Go postsynapse (go_0098794)
Go plasma membrane protein complex (go_0098797)
Go mitochondrial protein complex (go_0098798)
Go inner mitochondrial membrane protein complex (go_0098800)
Go respiratory chain complex (go_0098803)
Go whole membrane (go_0098805)
Go lytic vacuole membrane (go_0098852)
Go membrane microdomain (go_0098857)
Go actin-based cell projection (go_0098858)
Go cellular oxidant detoxification (go_0098869)
Go intrinsic component of presynaptic membrane (go_0098889)
Go intrinsic component of postsynaptic membrane (go_0098936)
Go glutamatergic synapse (go_0098978)
Go gaba-ergic synapse (go_0098982)
Go integral component of postsynaptic membrane (go_0099055)
Go integral component of presynaptic membrane (go_0099056)
Go regulation of trans-synaptic signaling (go_0099177)
Go intrinsic component of synaptic membrane (go_0099240)
Go secretory vesicle (go_0099503)
Go cytoplasmic region (go_0099568)
Go postsynaptic specialization (go_0099572)
Go integral component of synaptic membrane (go_0099699)
Go regulation of tumor necrosis factor superfamily cytokine production (go_1903555)
Go plasma membrane bounded cell projection organization (go_0120036)
Go plasma membrane bounded cell projection morphogenesis (go_0120039)
Go catalytic activity, acting on a trna (go_0140101)
Go carbohydrate derivative metabolic process (go_1901135)
Go carbohydrate derivative catabolic process (go_1901136)
Go carbohydrate derivative biosynthetic process (go_1901137)
Go regulation of neuron death (go_1901214)
Go organic cyclic compound biosynthetic process (go_1901362)
Go organonitrogen compound catabolic process (go_1901565)
Go organonitrogen compound biosynthetic process (go_1901566)
Go organic hydroxy compound metabolic process (go_1901615)
Go organic hydroxy compound biosynthetic process (go_1901617)
Go cellular response to oxygen-containing compound (go_1901701)
Go regulation of leukocyte differentiation (go_1902105)
Go transmembrane transporter complex (go_1902495)
Go negative regulation of intracellular signal transduction (go_1902532)
Go positive regulation of intracellular signal transduction (go_1902533)
Go secondary alcohol metabolic process (go_1902652)
Go secondary alcohol biosynthetic process (go_1902653)
Go regulation of leukocyte cell-cell adhesion (go_1903037)
Go liposaccharide metabolic process (go_1903509)
Go regulation of secretion by cell (go_1903530)
Go positive regulation of secretion by cell (go_1903532)
Go positive regulation of tumor necrosis factor superfamily cytokine production (go_1903557)
Go regulation of hemopoiesis (go_1903706)
Go positive regulation of hemopoiesis (go_1903708)
Go organic acid transmembrane transport (go_1903825)
Go regulation of cation transmembrane transport (go_1904062)
Go carboxylic acid transmembrane transport (go_1905039)
Go peptidase complex (go_1905368)
Go endopeptidase complex (go_1905369)
Go oxidoreductase complex (go_1990204)
Go transferase complex (go_1990234)
Go neutrophil migration (go_1990266)
Go transporter complex (go_1990351)
Go sequence-specific double-stranded dna binding (go_1990837)
Go ribonucleoprotein complex (go_1990904)
Go regulation of cell motility (go_2000145)
Go positive regulation of cell motility (go_2000147)
Go regulation of apoptotic signaling pathway (go_2001233)
Go regulation of cation channel activity (go_2001257)
mean genset / Marioni GWAS genes
GWAS (Marioni et al.) AD Marioni p < 0.0001
GWAS (Marioni et al.) AD Marioni p < 0.0005
GWAS (Marioni et al.) AD Marioni p < 0.001
GWAS (Marioni et al.) AD Marioni p < 0.005
GWAS (Marioni et al.) AD Marioni p < 0.01
GWAS (Marioni et al.) AD Marioni p < 0.05
GWAS (Marioni et al.) AD Marioni p < 1e-05
GWAS (Marioni et al.) AD Marioni p < 1e-06
GWAS (Marioni et al.) AD Marioni p < 5e-05
GWAS (Marioni et al.) AD Marioni p < 5e-06
mean genset / Zeisel 2015 celltypes
Celltype A1
Celltype A2
Celltype DAM
Celltype Zeisel Astrocyte
Celltype Zeisel CA1 Pyramidal
Celltype Zeisel Endothelial
Celltype Zeisel Ependymal
Celltype Zeisel Interneuron
Celltype Zeisel Microglia
Celltype Zeisel Mural
Celltype Zeisel Oligodendrocyte
Celltype Zeisel Pyramidal
Celltype Zeisel S1 Pyramidal
IHC score
Abeta
Gfap
Dapi
Neun
Abeta 200
Gfap 200
Dapi 200
Neun 200
Metadata
Age
Genotype
Group
X axis log1p(score)
Y axis
Category
geneset / WGCNA co-expression modules
geneset / GO categories
geneset / Marioni GWAS genes
geneset / Celltypes
Spot score
Statistic
Mean Expression
Diff. Expression Genotype
Diff. Expression ABeta
Gene
mean geneset / co-expression modules
WGCNA black
WGCNA blue
WGCNA brown
WGCNA green
WGCNA greenyellow
WGCNA magenta
WGCNA pink
WGCNA PIGS (purple)
WGCNA OLIG (red)
WGCNA tan
WGCNA turquoise
WGCNA yellow
mean genset / GO categories
Go ribosomal small subunit assembly (go_0000028)
Go g protein-coupled receptor binding (go_0001664)
Go lytic vacuole (go_0000323)
Go negative regulation of transcription by rna polymerase ii (go_0000122)
Go proteasome complex (go_0000502)
Go cell morphogenesis (go_0000902)
Go rna polymerase ii regulatory region sequence-specific dna binding (go_0000977)
Go transcription regulatory region sequence-specific dna binding (go_0000976)
Go antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii (go_0002504)
Go rna polymerase ii proximal promoter sequence-specific dna binding (go_0000978)
Go dna-binding transcription factor activity, rna polymerase ii-specific (go_0000981)
Go proximal promoter sequence-specific dna binding (go_0000987)
Go rna polymerase ii regulatory region dna binding (go_0001012)
Go regulatory region nucleic acid binding (go_0001067)
Go <unknown category> (go_0001077)
Go dna-binding transcription activator activity, rna polymerase ii-specific (go_0001228)
Go regulation of neurotransmitter levels (go_0001505)
Go microglial cell activation (go_0001774)
Go cell activation (go_0001775)
Go regulation of cytokine production (go_0001817)
Go negative regulation of cytokine production (go_0001818)
Go positive regulation of cytokine production (go_0001819)
Go positive regulation of protein phosphorylation (go_0001934)
Go cytoplasmic translation (go_0002181)
Go response to molecule of bacterial origin (go_0002237)
Go adaptive immune response (go_0002250)
Go immune effector process (go_0002252)
Go activation of immune response (go_0002253)
Go myeloid leukocyte activation (go_0002274)
Go leukocyte mediated immunity (go_0002443)
Go lymphocyte mediated immunity (go_0002449)
Go antigen processing and presentation of exogenous peptide antigen (go_0002478)
Go adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002460)
Go antigen processing and presentation of peptide antigen via mhc class ii (go_0002495)
Go regulation of leukocyte migration (go_0002685)
Go leukocyte differentiation (go_0002521)
Go monovalent inorganic cation transmembrane transporter activity (go_0015077)
Go regulation of antigen processing and presentation (go_0002577)
Go positive regulation of antigen processing and presentation (go_0002579)
Go negative regulation of immune system process (go_0002683)
Go positive regulation of immune system process (go_0002684)
Go positive regulation of leukocyte migration (go_0002687)
Go regulation of leukocyte activation (go_0002694)
Go negative regulation of leukocyte activation (go_0002695)
Go positive regulation of leukocyte activation (go_0002696)
Go regulation of immune effector process (go_0002697)
Go positive regulation of immune effector process (go_0002699)
Go regulation of leukocyte mediated immunity (go_0002703)
Go regulation of adaptive immune response (go_0002819)
Go positive regulation of adaptive immune response (go_0002821)
Go regulation of b cell apoptotic process (go_0002902)
Go regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002822)
Go cilium movement (go_0003341)
Go developmental process involved in reproduction (go_0003006)
Go chromatin binding (go_0003682)
Go double-stranded dna binding (go_0003690)
Go dna-binding transcription factor activity (go_0003700)
Go transcription coregulator activity (go_0003712)
Go structural constituent of ribosome (go_0003735)
Go structural constituent of ribosome (go_0003735)
Go motor activity (go_0003774)
Go cytochrome-c oxidase activity (go_0004129)
Go cysteine-type endopeptidase activity (go_0004197)
Go hydrolase activity, hydrolyzing o-glycosyl compounds (go_0004553)
Go hormone activity (go_0005179)
Go neuropeptide hormone activity (go_0005184)
Go neuropeptide hormone activity (go_0005184)
Go structural molecule activity (go_0005198)
Go extracellular matrix structural constituent (go_0005201)
Go ion channel activity (go_0005216)
Go cation channel activity (go_0005261)
Go calcium ion binding (go_0005509)
Go glycosaminoglycan binding (go_0005539)
Go mitochondrial outer membrane (go_0005741)
Go mitochondrial inner membrane (go_0005743)
Go mitochondrial respiratory chain complex i (go_0005747)
Go lysosome (go_0005764)
Go lysosomal membrane (go_0005765)
Go endosome (go_0005768)
Go early endosome (go_0005769)
Go late endosome (go_0005770)
Go vacuole (go_0005773)
Go vacuolar membrane (go_0005774)
Go endoplasmic reticulum membrane (go_0005789)
Go ribosome (go_0005840)
Go cell-cell junction (go_0005911)
Go carbohydrate metabolic process (go_0005975)
Go alcohol metabolic process (go_0006066)
Go organic acid metabolic process (go_0006082)
Go translation (go_0006412)
Go protein folding (go_0006457)
Go ubiquitin-dependent protein catabolic process (go_0006511)
Go peptide metabolic process (go_0006518)
Go membrane lipid metabolic process (go_0006643)
Go cellular amino acid metabolic process (go_0006520)
Go phospholipid metabolic process (go_0006644)
Go glycerophospholipid metabolic process (go_0006650)
Go glycolipid metabolic process (go_0006664)
Go sphingolipid metabolic process (go_0006665)
Go ceramide metabolic process (go_0006672)
Go steroid biosynthetic process (go_0006694)
Go cholesterol biosynthetic process (go_0006695)
Go coenzyme metabolic process (go_0006732)
Go nucleoside phosphate metabolic process (go_0006753)
Go cation transport (go_0006812)
Go neurotransmitter transport (go_0006836)
Go mitochondrial transport (go_0006839)
Go amino acid transport (go_0006865)
Go intracellular protein transport (go_0006886)
Go endocytosis (go_0006897)
Go autophagy (go_0006914)
Go chemotaxis (go_0006935)
Go defense response (go_0006952)
Go inflammatory response (go_0006954)
Go immune response (go_0006955)
Go immune response (go_0006955)
Go mitochondrion organization (go_0007005)
Go cytoskeleton organization (go_0007010)
Go microtubule-based process (go_0007017)
Go vacuole organization (go_0007033)
Go cell adhesion (go_0007155)
Go leukocyte cell-cell adhesion (go_0007159)
Go heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (go_0007157)
Go negative regulation of cell adhesion (go_0007162)
Go enzyme linked receptor protein signaling pathway (go_0007167)
Go neuropeptide signaling pathway (go_0007218)
Go neuropeptide signaling pathway (go_0007218)
Go small gtpase mediated signal transduction (go_0007264)
Go ensheathment of neurons (go_0007272)
Go pattern specification process (go_0007389)
Go nervous system development (go_0007399)
Go axon guidance (go_0007411)
Go heart development (go_0007507)
Go behavior (go_0007610)
Go learning or memory (go_0007611)
Go memory (go_0007613)
Go locomotory behavior (go_0007626)
Go feeding behavior (go_0007631)
Go chemokine activity (go_0008009)
Go beta-catenin binding (go_0008013)
Go synaptic vesicle (go_0008021)
Go enzyme activator activity (go_0008047)
Go cytoskeletal protein binding (go_0008092)
Go steroid metabolic process (go_0008202)
Go cholesterol metabolic process (go_0008203)
Go regulation of blood pressure (go_0008217)
Go cell population proliferation (go_0008283)
Go positive regulation of cell population proliferation (go_0008284)
Go negative regulation of cell population proliferation (go_0008285)
Go lipid binding (go_0008289)
Go cation transmembrane transporter activity (go_0008324)
Go regulation of cell shape (go_0008360)
Go axon ensheathment (go_0008366)
Go atp-dependent microtubule motor activity, minus-end-directed (go_0008569)
Go lipid biosynthetic process (go_0008610)
Go phospholipid biosynthetic process (go_0008654)
Go macromolecule catabolic process (go_0009057)
Go macromolecule biosynthetic process (go_0009059)
Go nucleotide metabolic process (go_0009117)
Go nucleotide biosynthetic process (go_0009165)
Go ribonucleotide biosynthetic process (go_0009260)
Go response to biotic stimulus (go_0009607)
Go response to virus (go_0009615)
Go response to bacterium (go_0009617)
Go axis specification (go_0009798)
Go animal organ morphogenesis (go_0009887)
Go tissue development (go_0009888)
Go regulation of catabolic process (go_0009894)
Go positive regulation of catabolic process (go_0009896)
Go external side of plasma membrane (go_0009897)
Go cell surface (go_0009986)
Go proteasomal protein catabolic process (go_0010498)
Go regulation of autophagy (go_0010506)
Go regulation of hormone levels (go_0010817)
Go positive regulation of cell development (go_0010720)
Go regulation of cell morphogenesis involved in differentiation (go_0010769)
Go positive regulation of cell death (go_0010942)
Go regulation of metal ion transport (go_0010959)
Go regulation of neuron projection development (go_0010975)
Go postsynaptic density (go_0014069)
Go ion transmembrane transporter activity (go_0015075)
Go proteasome-mediated ubiquitin-dependent protein catabolic process (go_0043161)
Go secondary active transmembrane transporter activity (go_0015291)
Go inorganic molecular entity transmembrane transporter activity (go_0015318)
Go tubulin binding (go_0015631)
Go large ribosomal subunit (go_0015934)
Go small ribosomal subunit (go_0015935)
Go immunoglobulin mediated immune response (go_0016064)
Go sterol metabolic process (go_0016125)
Go sterol biosynthetic process (go_0016126)
Go vesicle-mediated transport (go_0016192)
Go positive regulation of macroautophagy (go_0016239)
Go regulation of macroautophagy (go_0016241)
Go cell migration (go_0016477)
Go oxidoreductase activity (go_0016491)
Go oxidoreductase activity, acting on nad(p)h (go_0016651)
Go heterocycle biosynthetic process (go_0018130)
Go cytokine-mediated signaling pathway (go_0019221)
Go aromatic compound biosynthetic process (go_0019438)
Go organophosphate metabolic process (go_0019637)
Go ribose phosphate metabolic process (go_0019693)
Go b cell mediated immunity (go_0019724)
Go cellular homeostasis (go_0019725)
Go carboxylic acid metabolic process (go_0019752)
Go rrna binding (go_0019843)
Go organelle inner membrane (go_0019866)
Go outer membrane (go_0019867)
Go antigen processing and presentation (go_0019882)
Go antigen processing and presentation of exogenous antigen (go_0019884)
Go kinase binding (go_0019900)
Go central nervous system myelination (go_0022010)
Go antigen processing and presentation of exogenous peptide antigen via mhc class ii (go_0019886)
Go structural constituent of myelin sheath (go_0019911)
Go modification-dependent protein catabolic process (go_0019941)
Go cell cycle process (go_0022402)
Go regulation of cell-cell adhesion (go_0022407)
Go positive regulation of cell-cell adhesion (go_0022409)
Go cellular component disassembly (go_0022411)
Go regulation of cell morphogenesis (go_0022604)
Go biological adhesion (go_0022610)
Go cytosolic large ribosomal subunit (go_0022625)
Go cytosolic small ribosomal subunit (go_0022627)
Go active transmembrane transporter activity (go_0022804)
Go <unknown category> (go_0022838)
Go transmembrane transporter activity (go_0022857)
Go inorganic cation transmembrane transporter activity (go_0022890)
Go regulation of transmembrane transporter activity (go_0022898)
Go signaling (go_0023052)
Go cell projection organization (go_0030030)
Go regulation of endocytosis (go_0030100)
Go transport vesicle (go_0030133)
Go regulation of cell adhesion (go_0030155)
Go regulation of proteolysis (go_0030162)
Go protein catabolic process (go_0030163)
Go integral component of endoplasmic reticulum membrane (go_0030176)
Go neuron differentiation (go_0030182)
Go carbohydrate binding (go_0030246)
Go regulation of cell migration (go_0030334)
Go positive regulation of cell migration (go_0030335)
Go positive regulation of cell migration (go_0030335)
Go dendrite (go_0030425)
Go ubiquitin-dependent erad pathway (go_0030433)
Go receptor regulator activity (go_0030545)
Go neutrophil chemotaxis (go_0030593)
Go neutrophil chemotaxis (go_0030593)
Go leukocyte chemotaxis (go_0030595)
Go regulation of b cell proliferation (go_0030888)
Go nadh dehydrogenase complex (go_0030964)
Go secretion by cell (go_0032940)
Go extracellular matrix (go_0031012)
Go neuron projection development (go_0031175)
Go intrinsic component of endoplasmic reticulum membrane (go_0031227)
Go intrinsic component of organelle membrane (go_0031300)
Go regulation of cellular catabolic process (go_0031329)
Go regulation of cell projection organization (go_0031344)
Go positive regulation of cell projection organization (go_0031346)
Go regulation of defense response (go_0031347)
Go positive regulation of defense response (go_0031349)
Go regulation of neurological system process (go_0031644)
Go haptoglobin-hemoglobin complex (go_0031838)
Go mitochondrial membrane (go_0031966)
Go organelle outer membrane (go_0031968)
Go membrane-enclosed lumen (go_0031974)
Go regulation of response to external stimulus (go_0032101)
Go negative regulation of response to external stimulus (go_0032102)
Go positive regulation of response to external stimulus (go_0032103)
Go axon ensheathment in central nervous system (go_0032291)
Go regulation of intracellular transport (go_0032386)
Go regulation of transporter activity (go_0032409)
Go regulation of ion transmembrane transporter activity (go_0032412)
Go regulation of interleukin-6 production (go_0032675)
Go regulation of tumor necrosis factor production (go_0032680)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go regulation of protein localization (go_0032880)
Go regulation of mononuclear cell proliferation (go_0032944)
Go cellular component morphogenesis (go_0032989)
Go amide binding (go_0033218)
Go axon part (go_0033267)
Go positive regulation of kinase activity (go_0033674)
Go response to lipid (go_0033993)
Go response to cytokine (go_0034097)
Go ion transmembrane transport (go_0034220)
Go response to interferon-gamma (go_0034341)
Go cellular protein localization (go_0034613)
Go cellular protein-containing complex assembly (go_0034622)
Go cellular macromolecule biosynthetic process (go_0034645)
Go ncrna metabolic process (go_0034660)
Go ion channel complex (go_0034702)
Go cation channel complex (go_0034703)
Go regulation of transmembrane transport (go_0034762)
Go regulation of ion transmembrane transport (go_0034765)
Go response to endoplasmic reticulum stress (go_0034976)
Go non-canonical wnt signaling pathway (go_0035567)
Go erad pathway (go_0036503)
Go locomotion (go_0040011)
Go regulation of locomotion (go_0040012)
Go positive regulation of locomotion (go_0040017)
Go regulation of t cell proliferation (go_0042129)
Go regulation of protein catabolic process (go_0042176)
Go ribosomal small subunit biogenesis (go_0042274)
Go peptide binding (go_0042277)
Go positive regulation of phosphorylation (go_0042327)
Go taxis (go_0042330)
Go regulation of membrane potential (go_0042391)
Go myelination (go_0042552)
Go mhc protein complex (go_0042611)
Go antigen processing and presentation of exogenous peptide antigen via mhc class i (go_0042590)
Go mhc class ii protein complex (go_0042613)
Go mhc class ii protein complex (go_0042613)
Go polysomal ribosome (go_0042788)
Go protein homodimerization activity (go_0042803)
Go neuronal cell body (go_0043025)
Go peptide biosynthetic process (go_0043043)
Go response to external biotic stimulus (go_0043207)
Go dendritic spine (go_0043197)
Go positive regulation of mapk cascade (go_0043410)
Go myelin sheath (go_0043209)
Go myelin sheath (go_0043209)
Go organelle lumen (go_0043233)
Go receptor complex (go_0043235)
Go regulation of ion transport (go_0043269)
Go regulation of protein complex assembly (go_0043254)
Go regulation of mapk cascade (go_0043408)
Go positive regulation of endocytosis (go_0045807)
Go oxoacid metabolic process (go_0043436)
Go positive regulation of cellular component biogenesis (go_0044089)
Go cellular amide metabolic process (go_0043603)
Go amide biosynthetic process (go_0043604)
Go regulation of multi-organism process (go_0043900)
Go modification-dependent macromolecule catabolic process (go_0043632)
Go regulation of system process (go_0044057)
Go regulation of cellular component biogenesis (go_0044087)
Go antigen processing and presentation of peptide antigen (go_0048002)
Go transcription regulatory region dna binding (go_0044212)
Go cellular lipid metabolic process (go_0044255)
Go cellular macromolecule catabolic process (go_0044265)
Go small molecule biosynthetic process (go_0044283)
Go cell body (go_0044297)
Go neuron spine (go_0044309)
Go ubiquitin-like protein ligase binding (go_0044389)
Go ribosomal subunit (go_0044391)
Go mitochondrial part (go_0044429)
Go golgi apparatus part (go_0044431)
Go endoplasmic reticulum part (go_0044432)
Go cytoplasmic vesicle part (go_0044433)
Go vacuolar part (go_0044437)
Go endosomal part (go_0044440)
Go ciliary part (go_0044441)
Go cytosolic part (go_0044445)
Go axoneme part (go_0044447)
Go mitochondrial membrane part (go_0044455)
Go innate immune response (go_0045087)
Go membrane raft (go_0045121)
Go postsynaptic membrane (go_0045211)
Go respiratory chain complex i (go_0045271)
Go leukocyte activation (go_0045321)
Go dynein light chain binding (go_0045503)
Go dynein intermediate chain binding (go_0045505)
Go negative regulation of cell differentiation (go_0045596)
Go regulation of myeloid cell differentiation (go_0045637)
Go regulation of neuron differentiation (go_0045664)
Go alcohol biosynthetic process (go_0046165)
Go ribose phosphate biosynthetic process (go_0046390)
Go glycerolipid metabolic process (go_0046486)
Go phosphatidylinositol metabolic process (go_0046488)
Go metal ion transmembrane transporter activity (go_0046873)
Go protein heterodimerization activity (go_0046982)
Go perinuclear region of cytoplasm (go_0048471)
Go cofactor binding (go_0048037)
Go golgi vesicle transport (go_0048193)
Go lymphocyte chemotaxis (go_0048247)
Go cell development (go_0048468)
Go neuron projection morphogenesis (go_0048812)
Go rhythmic process (go_0048511)
Go embryonic morphogenesis (go_0048598)
Go neuron development (go_0048666)
Go multicellular organismal reproductive process (go_0048609)
Go anatomical structure formation involved in morphogenesis (go_0048646)
Go regulation of smooth muscle cell proliferation (go_0048660)
Go tissue morphogenesis (go_0048729)
Go system development (go_0048731)
Go positive regulation of cellular component movement (go_0051272)
Go cell projection morphogenesis (go_0048858)
Go cell motility (go_0048870)
Go coenzyme binding (go_0050662)
Go regulation of lymphocyte proliferation (go_0050670)
Go regulation of epithelial cell proliferation (go_0050678)
Go regulation of inflammatory response (go_0050727)
Go regulation of neurogenesis (go_0050767)
Go positive regulation of neurogenesis (go_0050769)
Go regulation of immune response (go_0050776)
Go positive regulation of immune response (go_0050778)
Go ion homeostasis (go_0050801)
Go modulation of chemical synaptic transmission (go_0050804)
Go regulation of synapse organization (go_0050807)
Go cell adhesion molecule binding (go_0050839)
Go regulation of t cell activation (go_0050863)
Go regulation of cell activation (go_0050865)
Go cognition (go_0050890)
Go negative regulation of cell activation (go_0050866)
Go positive regulation of cell activation (go_0050867)
Go positive regulation of t cell activation (go_0050870)
Go leukocyte migration (go_0050900)
Go positive regulation of chemotaxis (go_0050921)
Go actin filament binding (go_0051015)
Go regulation of secretion (go_0051046)
Go cofactor metabolic process (go_0051186)
Go regulation of lymphocyte activation (go_0051249)
Go positive regulation of lymphocyte activation (go_0051251)
Go regulation of cellular component movement (go_0051270)
Go positive regulation of nervous system development (go_0051962)
Go regulation of hydrolase activity (go_0051336)
Go positive regulation of hydrolase activity (go_0051345)
Go positive regulation of transferase activity (go_0051347)
Go defense response to virus (go_0051607)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go multi-organism process (go_0051704)
Go response to other organism (go_0051707)
Go regulation of calcium ion transport (go_0051924)
Go dynein light intermediate chain binding (go_0051959)
Go oxidation-reduction process (go_0055114)
Go transmembrane transport (go_0055085)
Go regulation of plasma membrane bounded cell projection organization (go_0120035)
Go nucleobase-containing small molecule metabolic process (go_0055086)
Go cell chemotaxis (go_0060326)
Go regulation of cellular localization (go_0060341)
Go epithelium development (go_0060429)
Go nucleoside-triphosphatase regulator activity (go_0060589)
Go regulation of vesicle-mediated transport (go_0060627)
Go membrane organization (go_0061024)
Go process utilizing autophagic mechanism (go_0061919)
Go collagen-containing extracellular matrix (go_0062023)
Go intracellular organelle lumen (go_0070013)
Go large ribosomal subunit rrna binding (go_0070180)
Go regulation of establishment of protein localization (go_0070201)
Go regulation of erk1 and erk2 cascade (go_0070372)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go exocytic vesicle (go_0070382)
Go respirasome (go_0070469)
Go protein localization to mitochondrion (go_0070585)
Go regulation of leukocyte proliferation (go_0070663)
Go positive regulation of leukocyte proliferation (go_0070665)
Go cellular macromolecule localization (go_0070727)
Go cellular response to biotic stimulus (go_0071216)
Go cellular response to molecule of bacterial origin (go_0071219)
Go cellular response to cytokine stimulus (go_0071345)
Go cellular response to interferon-gamma (go_0071346)
Go granulocyte chemotaxis (go_0071621)
Go ribonucleoprotein complex subunit organization (go_0071826)
Go neuropeptide receptor binding (go_0071855)
Go cellular divalent inorganic cation homeostasis (go_0072503)
Go divalent inorganic cation homeostasis (go_0072507)
Go establishment of protein localization to organelle (go_0072594)
Go establishment of protein localization to mitochondrion (go_0072655)
Go lymphocyte migration (go_0072676)
Go organophosphate biosynthetic process (go_0090407)
Go synaptic membrane (go_0097060)
Go neuron projection guidance (go_0097485)
Go myeloid leukocyte migration (go_0097529)
Go granulocyte migration (go_0097530)
Go defense response to other organism (go_0098542)
Go side of membrane (go_0098552)
Go bounding membrane of organelle (go_0098588)
Go membrane region (go_0098589)
Go cell-cell adhesion (go_0098609)
Go anion transmembrane transport (go_0098656)
Go import into cell (go_0098657)
Go cell-cell adhesion via plasma-membrane adhesion molecules (go_0098742)
Go presynapse (go_0098793)
Go postsynapse (go_0098794)
Go plasma membrane protein complex (go_0098797)
Go mitochondrial protein complex (go_0098798)
Go inner mitochondrial membrane protein complex (go_0098800)
Go respiratory chain complex (go_0098803)
Go whole membrane (go_0098805)
Go lytic vacuole membrane (go_0098852)
Go membrane microdomain (go_0098857)
Go actin-based cell projection (go_0098858)
Go cellular oxidant detoxification (go_0098869)
Go intrinsic component of presynaptic membrane (go_0098889)
Go intrinsic component of postsynaptic membrane (go_0098936)
Go glutamatergic synapse (go_0098978)
Go gaba-ergic synapse (go_0098982)
Go integral component of postsynaptic membrane (go_0099055)
Go integral component of presynaptic membrane (go_0099056)
Go regulation of trans-synaptic signaling (go_0099177)
Go intrinsic component of synaptic membrane (go_0099240)
Go secretory vesicle (go_0099503)
Go cytoplasmic region (go_0099568)
Go postsynaptic specialization (go_0099572)
Go integral component of synaptic membrane (go_0099699)
Go regulation of tumor necrosis factor superfamily cytokine production (go_1903555)
Go plasma membrane bounded cell projection organization (go_0120036)
Go plasma membrane bounded cell projection morphogenesis (go_0120039)
Go catalytic activity, acting on a trna (go_0140101)
Go carbohydrate derivative metabolic process (go_1901135)
Go carbohydrate derivative catabolic process (go_1901136)
Go carbohydrate derivative biosynthetic process (go_1901137)
Go regulation of neuron death (go_1901214)
Go organic cyclic compound biosynthetic process (go_1901362)
Go organonitrogen compound catabolic process (go_1901565)
Go organonitrogen compound biosynthetic process (go_1901566)
Go organic hydroxy compound metabolic process (go_1901615)
Go organic hydroxy compound biosynthetic process (go_1901617)
Go cellular response to oxygen-containing compound (go_1901701)
Go regulation of leukocyte differentiation (go_1902105)
Go transmembrane transporter complex (go_1902495)
Go negative regulation of intracellular signal transduction (go_1902532)
Go positive regulation of intracellular signal transduction (go_1902533)
Go secondary alcohol metabolic process (go_1902652)
Go secondary alcohol biosynthetic process (go_1902653)
Go regulation of leukocyte cell-cell adhesion (go_1903037)
Go liposaccharide metabolic process (go_1903509)
Go regulation of secretion by cell (go_1903530)
Go positive regulation of secretion by cell (go_1903532)
Go positive regulation of tumor necrosis factor superfamily cytokine production (go_1903557)
Go regulation of hemopoiesis (go_1903706)
Go positive regulation of hemopoiesis (go_1903708)
Go organic acid transmembrane transport (go_1903825)
Go regulation of cation transmembrane transport (go_1904062)
Go carboxylic acid transmembrane transport (go_1905039)
Go peptidase complex (go_1905368)
Go endopeptidase complex (go_1905369)
Go oxidoreductase complex (go_1990204)
Go transferase complex (go_1990234)
Go neutrophil migration (go_1990266)
Go transporter complex (go_1990351)
Go sequence-specific double-stranded dna binding (go_1990837)
Go ribonucleoprotein complex (go_1990904)
Go regulation of cell motility (go_2000145)
Go positive regulation of cell motility (go_2000147)
Go regulation of apoptotic signaling pathway (go_2001233)
Go regulation of cation channel activity (go_2001257)
mean genset / Marioni GWAS genes
GWAS (Marioni et al.) AD Marioni p < 0.0001
GWAS (Marioni et al.) AD Marioni p < 0.0005
GWAS (Marioni et al.) AD Marioni p < 0.001
GWAS (Marioni et al.) AD Marioni p < 0.005
GWAS (Marioni et al.) AD Marioni p < 0.01
GWAS (Marioni et al.) AD Marioni p < 0.05
GWAS (Marioni et al.) AD Marioni p < 1e-05
GWAS (Marioni et al.) AD Marioni p < 1e-06
GWAS (Marioni et al.) AD Marioni p < 5e-05
GWAS (Marioni et al.) AD Marioni p < 5e-06
mean genset / Zeisel 2015 celltypes
Celltype A1
Celltype A2
Celltype DAM
Celltype Zeisel Astrocyte
Celltype Zeisel CA1 Pyramidal
Celltype Zeisel Endothelial
Celltype Zeisel Ependymal
Celltype Zeisel Interneuron
Celltype Zeisel Microglia
Celltype Zeisel Mural
Celltype Zeisel Oligodendrocyte
Celltype Zeisel Pyramidal
Celltype Zeisel S1 Pyramidal
IHC score
Abeta
Gfap
Dapi
Neun
Abeta 200
Gfap 200
Dapi 200
Neun 200
Metadata
Age
Genotype
Group
X axis log1p(score)
Color
Category
geneset / WGCNA co-expression modules
geneset / GO categories
geneset / Marioni GWAS genes
geneset / Celltypes
Spot score
Experimental group
Statistic
Mean Expression
Diff. Expression Genotype
Diff. Expression ABeta
Color gene
mean geneset / co-expression modules
WGCNA black
WGCNA blue
WGCNA brown
WGCNA green
WGCNA greenyellow
WGCNA magenta
WGCNA pink
WGCNA PIGS (purple)
WGCNA OLIG (red)
WGCNA tan
WGCNA turquoise
WGCNA yellow
mean genset / GO categories
Go ribosomal small subunit assembly (go_0000028)
Go g protein-coupled receptor binding (go_0001664)
Go lytic vacuole (go_0000323)
Go negative regulation of transcription by rna polymerase ii (go_0000122)
Go proteasome complex (go_0000502)
Go cell morphogenesis (go_0000902)
Go rna polymerase ii regulatory region sequence-specific dna binding (go_0000977)
Go transcription regulatory region sequence-specific dna binding (go_0000976)
Go antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii (go_0002504)
Go rna polymerase ii proximal promoter sequence-specific dna binding (go_0000978)
Go dna-binding transcription factor activity, rna polymerase ii-specific (go_0000981)
Go proximal promoter sequence-specific dna binding (go_0000987)
Go rna polymerase ii regulatory region dna binding (go_0001012)
Go regulatory region nucleic acid binding (go_0001067)
Go <unknown category> (go_0001077)
Go dna-binding transcription activator activity, rna polymerase ii-specific (go_0001228)
Go regulation of neurotransmitter levels (go_0001505)
Go microglial cell activation (go_0001774)
Go cell activation (go_0001775)
Go regulation of cytokine production (go_0001817)
Go negative regulation of cytokine production (go_0001818)
Go positive regulation of cytokine production (go_0001819)
Go positive regulation of protein phosphorylation (go_0001934)
Go cytoplasmic translation (go_0002181)
Go response to molecule of bacterial origin (go_0002237)
Go adaptive immune response (go_0002250)
Go immune effector process (go_0002252)
Go activation of immune response (go_0002253)
Go myeloid leukocyte activation (go_0002274)
Go leukocyte mediated immunity (go_0002443)
Go lymphocyte mediated immunity (go_0002449)
Go antigen processing and presentation of exogenous peptide antigen (go_0002478)
Go adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002460)
Go antigen processing and presentation of peptide antigen via mhc class ii (go_0002495)
Go regulation of leukocyte migration (go_0002685)
Go leukocyte differentiation (go_0002521)
Go monovalent inorganic cation transmembrane transporter activity (go_0015077)
Go regulation of antigen processing and presentation (go_0002577)
Go positive regulation of antigen processing and presentation (go_0002579)
Go negative regulation of immune system process (go_0002683)
Go positive regulation of immune system process (go_0002684)
Go positive regulation of leukocyte migration (go_0002687)
Go regulation of leukocyte activation (go_0002694)
Go negative regulation of leukocyte activation (go_0002695)
Go positive regulation of leukocyte activation (go_0002696)
Go regulation of immune effector process (go_0002697)
Go positive regulation of immune effector process (go_0002699)
Go regulation of leukocyte mediated immunity (go_0002703)
Go regulation of adaptive immune response (go_0002819)
Go positive regulation of adaptive immune response (go_0002821)
Go regulation of b cell apoptotic process (go_0002902)
Go regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (go_0002822)
Go cilium movement (go_0003341)
Go developmental process involved in reproduction (go_0003006)
Go chromatin binding (go_0003682)
Go double-stranded dna binding (go_0003690)
Go dna-binding transcription factor activity (go_0003700)
Go transcription coregulator activity (go_0003712)
Go structural constituent of ribosome (go_0003735)
Go structural constituent of ribosome (go_0003735)
Go motor activity (go_0003774)
Go cytochrome-c oxidase activity (go_0004129)
Go cysteine-type endopeptidase activity (go_0004197)
Go hydrolase activity, hydrolyzing o-glycosyl compounds (go_0004553)
Go hormone activity (go_0005179)
Go neuropeptide hormone activity (go_0005184)
Go neuropeptide hormone activity (go_0005184)
Go structural molecule activity (go_0005198)
Go extracellular matrix structural constituent (go_0005201)
Go ion channel activity (go_0005216)
Go cation channel activity (go_0005261)
Go calcium ion binding (go_0005509)
Go glycosaminoglycan binding (go_0005539)
Go mitochondrial outer membrane (go_0005741)
Go mitochondrial inner membrane (go_0005743)
Go mitochondrial respiratory chain complex i (go_0005747)
Go lysosome (go_0005764)
Go lysosomal membrane (go_0005765)
Go endosome (go_0005768)
Go early endosome (go_0005769)
Go late endosome (go_0005770)
Go vacuole (go_0005773)
Go vacuolar membrane (go_0005774)
Go endoplasmic reticulum membrane (go_0005789)
Go ribosome (go_0005840)
Go cell-cell junction (go_0005911)
Go carbohydrate metabolic process (go_0005975)
Go alcohol metabolic process (go_0006066)
Go organic acid metabolic process (go_0006082)
Go translation (go_0006412)
Go protein folding (go_0006457)
Go ubiquitin-dependent protein catabolic process (go_0006511)
Go peptide metabolic process (go_0006518)
Go membrane lipid metabolic process (go_0006643)
Go cellular amino acid metabolic process (go_0006520)
Go phospholipid metabolic process (go_0006644)
Go glycerophospholipid metabolic process (go_0006650)
Go glycolipid metabolic process (go_0006664)
Go sphingolipid metabolic process (go_0006665)
Go ceramide metabolic process (go_0006672)
Go steroid biosynthetic process (go_0006694)
Go cholesterol biosynthetic process (go_0006695)
Go coenzyme metabolic process (go_0006732)
Go nucleoside phosphate metabolic process (go_0006753)
Go cation transport (go_0006812)
Go neurotransmitter transport (go_0006836)
Go mitochondrial transport (go_0006839)
Go amino acid transport (go_0006865)
Go intracellular protein transport (go_0006886)
Go endocytosis (go_0006897)
Go autophagy (go_0006914)
Go chemotaxis (go_0006935)
Go defense response (go_0006952)
Go inflammatory response (go_0006954)
Go immune response (go_0006955)
Go immune response (go_0006955)
Go mitochondrion organization (go_0007005)
Go cytoskeleton organization (go_0007010)
Go microtubule-based process (go_0007017)
Go vacuole organization (go_0007033)
Go cell adhesion (go_0007155)
Go leukocyte cell-cell adhesion (go_0007159)
Go heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (go_0007157)
Go negative regulation of cell adhesion (go_0007162)
Go enzyme linked receptor protein signaling pathway (go_0007167)
Go neuropeptide signaling pathway (go_0007218)
Go neuropeptide signaling pathway (go_0007218)
Go small gtpase mediated signal transduction (go_0007264)
Go ensheathment of neurons (go_0007272)
Go pattern specification process (go_0007389)
Go nervous system development (go_0007399)
Go axon guidance (go_0007411)
Go heart development (go_0007507)
Go behavior (go_0007610)
Go learning or memory (go_0007611)
Go memory (go_0007613)
Go locomotory behavior (go_0007626)
Go feeding behavior (go_0007631)
Go chemokine activity (go_0008009)
Go beta-catenin binding (go_0008013)
Go synaptic vesicle (go_0008021)
Go enzyme activator activity (go_0008047)
Go cytoskeletal protein binding (go_0008092)
Go steroid metabolic process (go_0008202)
Go cholesterol metabolic process (go_0008203)
Go regulation of blood pressure (go_0008217)
Go cell population proliferation (go_0008283)
Go positive regulation of cell population proliferation (go_0008284)
Go negative regulation of cell population proliferation (go_0008285)
Go lipid binding (go_0008289)
Go cation transmembrane transporter activity (go_0008324)
Go regulation of cell shape (go_0008360)
Go axon ensheathment (go_0008366)
Go atp-dependent microtubule motor activity, minus-end-directed (go_0008569)
Go lipid biosynthetic process (go_0008610)
Go phospholipid biosynthetic process (go_0008654)
Go macromolecule catabolic process (go_0009057)
Go macromolecule biosynthetic process (go_0009059)
Go nucleotide metabolic process (go_0009117)
Go nucleotide biosynthetic process (go_0009165)
Go ribonucleotide biosynthetic process (go_0009260)
Go response to biotic stimulus (go_0009607)
Go response to virus (go_0009615)
Go response to bacterium (go_0009617)
Go axis specification (go_0009798)
Go animal organ morphogenesis (go_0009887)
Go tissue development (go_0009888)
Go regulation of catabolic process (go_0009894)
Go positive regulation of catabolic process (go_0009896)
Go external side of plasma membrane (go_0009897)
Go cell surface (go_0009986)
Go proteasomal protein catabolic process (go_0010498)
Go regulation of autophagy (go_0010506)
Go regulation of hormone levels (go_0010817)
Go positive regulation of cell development (go_0010720)
Go regulation of cell morphogenesis involved in differentiation (go_0010769)
Go positive regulation of cell death (go_0010942)
Go regulation of metal ion transport (go_0010959)
Go regulation of neuron projection development (go_0010975)
Go postsynaptic density (go_0014069)
Go ion transmembrane transporter activity (go_0015075)
Go proteasome-mediated ubiquitin-dependent protein catabolic process (go_0043161)
Go secondary active transmembrane transporter activity (go_0015291)
Go inorganic molecular entity transmembrane transporter activity (go_0015318)
Go tubulin binding (go_0015631)
Go large ribosomal subunit (go_0015934)
Go small ribosomal subunit (go_0015935)
Go immunoglobulin mediated immune response (go_0016064)
Go sterol metabolic process (go_0016125)
Go sterol biosynthetic process (go_0016126)
Go vesicle-mediated transport (go_0016192)
Go positive regulation of macroautophagy (go_0016239)
Go regulation of macroautophagy (go_0016241)
Go cell migration (go_0016477)
Go oxidoreductase activity (go_0016491)
Go oxidoreductase activity, acting on nad(p)h (go_0016651)
Go heterocycle biosynthetic process (go_0018130)
Go cytokine-mediated signaling pathway (go_0019221)
Go aromatic compound biosynthetic process (go_0019438)
Go organophosphate metabolic process (go_0019637)
Go ribose phosphate metabolic process (go_0019693)
Go b cell mediated immunity (go_0019724)
Go cellular homeostasis (go_0019725)
Go carboxylic acid metabolic process (go_0019752)
Go rrna binding (go_0019843)
Go organelle inner membrane (go_0019866)
Go outer membrane (go_0019867)
Go antigen processing and presentation (go_0019882)
Go antigen processing and presentation of exogenous antigen (go_0019884)
Go kinase binding (go_0019900)
Go central nervous system myelination (go_0022010)
Go antigen processing and presentation of exogenous peptide antigen via mhc class ii (go_0019886)
Go structural constituent of myelin sheath (go_0019911)
Go modification-dependent protein catabolic process (go_0019941)
Go cell cycle process (go_0022402)
Go regulation of cell-cell adhesion (go_0022407)
Go positive regulation of cell-cell adhesion (go_0022409)
Go cellular component disassembly (go_0022411)
Go regulation of cell morphogenesis (go_0022604)
Go biological adhesion (go_0022610)
Go cytosolic large ribosomal subunit (go_0022625)
Go cytosolic small ribosomal subunit (go_0022627)
Go active transmembrane transporter activity (go_0022804)
Go <unknown category> (go_0022838)
Go transmembrane transporter activity (go_0022857)
Go inorganic cation transmembrane transporter activity (go_0022890)
Go regulation of transmembrane transporter activity (go_0022898)
Go signaling (go_0023052)
Go cell projection organization (go_0030030)
Go regulation of endocytosis (go_0030100)
Go transport vesicle (go_0030133)
Go regulation of cell adhesion (go_0030155)
Go regulation of proteolysis (go_0030162)
Go protein catabolic process (go_0030163)
Go integral component of endoplasmic reticulum membrane (go_0030176)
Go neuron differentiation (go_0030182)
Go carbohydrate binding (go_0030246)
Go regulation of cell migration (go_0030334)
Go positive regulation of cell migration (go_0030335)
Go positive regulation of cell migration (go_0030335)
Go dendrite (go_0030425)
Go ubiquitin-dependent erad pathway (go_0030433)
Go receptor regulator activity (go_0030545)
Go neutrophil chemotaxis (go_0030593)
Go neutrophil chemotaxis (go_0030593)
Go leukocyte chemotaxis (go_0030595)
Go regulation of b cell proliferation (go_0030888)
Go nadh dehydrogenase complex (go_0030964)
Go secretion by cell (go_0032940)
Go extracellular matrix (go_0031012)
Go neuron projection development (go_0031175)
Go intrinsic component of endoplasmic reticulum membrane (go_0031227)
Go intrinsic component of organelle membrane (go_0031300)
Go regulation of cellular catabolic process (go_0031329)
Go regulation of cell projection organization (go_0031344)
Go positive regulation of cell projection organization (go_0031346)
Go regulation of defense response (go_0031347)
Go positive regulation of defense response (go_0031349)
Go regulation of neurological system process (go_0031644)
Go haptoglobin-hemoglobin complex (go_0031838)
Go mitochondrial membrane (go_0031966)
Go organelle outer membrane (go_0031968)
Go membrane-enclosed lumen (go_0031974)
Go regulation of response to external stimulus (go_0032101)
Go negative regulation of response to external stimulus (go_0032102)
Go positive regulation of response to external stimulus (go_0032103)
Go axon ensheathment in central nervous system (go_0032291)
Go regulation of intracellular transport (go_0032386)
Go regulation of transporter activity (go_0032409)
Go regulation of ion transmembrane transporter activity (go_0032412)
Go regulation of interleukin-6 production (go_0032675)
Go regulation of tumor necrosis factor production (go_0032680)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go positive regulation of tumor necrosis factor production (go_0032760)
Go regulation of protein localization (go_0032880)
Go regulation of mononuclear cell proliferation (go_0032944)
Go cellular component morphogenesis (go_0032989)
Go amide binding (go_0033218)
Go axon part (go_0033267)
Go positive regulation of kinase activity (go_0033674)
Go response to lipid (go_0033993)
Go response to cytokine (go_0034097)
Go ion transmembrane transport (go_0034220)
Go response to interferon-gamma (go_0034341)
Go cellular protein localization (go_0034613)
Go cellular protein-containing complex assembly (go_0034622)
Go cellular macromolecule biosynthetic process (go_0034645)
Go ncrna metabolic process (go_0034660)
Go ion channel complex (go_0034702)
Go cation channel complex (go_0034703)
Go regulation of transmembrane transport (go_0034762)
Go regulation of ion transmembrane transport (go_0034765)
Go response to endoplasmic reticulum stress (go_0034976)
Go non-canonical wnt signaling pathway (go_0035567)
Go erad pathway (go_0036503)
Go locomotion (go_0040011)
Go regulation of locomotion (go_0040012)
Go positive regulation of locomotion (go_0040017)
Go regulation of t cell proliferation (go_0042129)
Go regulation of protein catabolic process (go_0042176)
Go ribosomal small subunit biogenesis (go_0042274)
Go peptide binding (go_0042277)
Go positive regulation of phosphorylation (go_0042327)
Go taxis (go_0042330)
Go regulation of membrane potential (go_0042391)
Go myelination (go_0042552)
Go mhc protein complex (go_0042611)
Go antigen processing and presentation of exogenous peptide antigen via mhc class i (go_0042590)
Go mhc class ii protein complex (go_0042613)
Go mhc class ii protein complex (go_0042613)
Go polysomal ribosome (go_0042788)
Go protein homodimerization activity (go_0042803)
Go neuronal cell body (go_0043025)
Go peptide biosynthetic process (go_0043043)
Go response to external biotic stimulus (go_0043207)
Go dendritic spine (go_0043197)
Go positive regulation of mapk cascade (go_0043410)
Go myelin sheath (go_0043209)
Go myelin sheath (go_0043209)
Go organelle lumen (go_0043233)
Go receptor complex (go_0043235)
Go regulation of ion transport (go_0043269)
Go regulation of protein complex assembly (go_0043254)
Go regulation of mapk cascade (go_0043408)
Go positive regulation of endocytosis (go_0045807)
Go oxoacid metabolic process (go_0043436)
Go positive regulation of cellular component biogenesis (go_0044089)
Go cellular amide metabolic process (go_0043603)
Go amide biosynthetic process (go_0043604)
Go regulation of multi-organism process (go_0043900)
Go modification-dependent macromolecule catabolic process (go_0043632)
Go regulation of system process (go_0044057)
Go regulation of cellular component biogenesis (go_0044087)
Go antigen processing and presentation of peptide antigen (go_0048002)
Go transcription regulatory region dna binding (go_0044212)
Go cellular lipid metabolic process (go_0044255)
Go cellular macromolecule catabolic process (go_0044265)
Go small molecule biosynthetic process (go_0044283)
Go cell body (go_0044297)
Go neuron spine (go_0044309)
Go ubiquitin-like protein ligase binding (go_0044389)
Go ribosomal subunit (go_0044391)
Go mitochondrial part (go_0044429)
Go golgi apparatus part (go_0044431)
Go endoplasmic reticulum part (go_0044432)
Go cytoplasmic vesicle part (go_0044433)
Go vacuolar part (go_0044437)
Go endosomal part (go_0044440)
Go ciliary part (go_0044441)
Go cytosolic part (go_0044445)
Go axoneme part (go_0044447)
Go mitochondrial membrane part (go_0044455)
Go innate immune response (go_0045087)
Go membrane raft (go_0045121)
Go postsynaptic membrane (go_0045211)
Go respiratory chain complex i (go_0045271)
Go leukocyte activation (go_0045321)
Go dynein light chain binding (go_0045503)
Go dynein intermediate chain binding (go_0045505)
Go negative regulation of cell differentiation (go_0045596)
Go regulation of myeloid cell differentiation (go_0045637)
Go regulation of neuron differentiation (go_0045664)
Go alcohol biosynthetic process (go_0046165)
Go ribose phosphate biosynthetic process (go_0046390)
Go glycerolipid metabolic process (go_0046486)
Go phosphatidylinositol metabolic process (go_0046488)
Go metal ion transmembrane transporter activity (go_0046873)
Go protein heterodimerization activity (go_0046982)
Go perinuclear region of cytoplasm (go_0048471)
Go cofactor binding (go_0048037)
Go golgi vesicle transport (go_0048193)
Go lymphocyte chemotaxis (go_0048247)
Go cell development (go_0048468)
Go neuron projection morphogenesis (go_0048812)
Go rhythmic process (go_0048511)
Go embryonic morphogenesis (go_0048598)
Go neuron development (go_0048666)
Go multicellular organismal reproductive process (go_0048609)
Go anatomical structure formation involved in morphogenesis (go_0048646)
Go regulation of smooth muscle cell proliferation (go_0048660)
Go tissue morphogenesis (go_0048729)
Go system development (go_0048731)
Go positive regulation of cellular component movement (go_0051272)
Go cell projection morphogenesis (go_0048858)
Go cell motility (go_0048870)
Go coenzyme binding (go_0050662)
Go regulation of lymphocyte proliferation (go_0050670)
Go regulation of epithelial cell proliferation (go_0050678)
Go regulation of inflammatory response (go_0050727)
Go regulation of neurogenesis (go_0050767)
Go positive regulation of neurogenesis (go_0050769)
Go regulation of immune response (go_0050776)
Go positive regulation of immune response (go_0050778)
Go ion homeostasis (go_0050801)
Go modulation of chemical synaptic transmission (go_0050804)
Go regulation of synapse organization (go_0050807)
Go cell adhesion molecule binding (go_0050839)
Go regulation of t cell activation (go_0050863)
Go regulation of cell activation (go_0050865)
Go cognition (go_0050890)
Go negative regulation of cell activation (go_0050866)
Go positive regulation of cell activation (go_0050867)
Go positive regulation of t cell activation (go_0050870)
Go leukocyte migration (go_0050900)
Go positive regulation of chemotaxis (go_0050921)
Go actin filament binding (go_0051015)
Go regulation of secretion (go_0051046)
Go cofactor metabolic process (go_0051186)
Go regulation of lymphocyte activation (go_0051249)
Go positive regulation of lymphocyte activation (go_0051251)
Go regulation of cellular component movement (go_0051270)
Go positive regulation of nervous system development (go_0051962)
Go regulation of hydrolase activity (go_0051336)
Go positive regulation of hydrolase activity (go_0051345)
Go positive regulation of transferase activity (go_0051347)
Go defense response to virus (go_0051607)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go proteolysis involved in cellular protein catabolic process (go_0051603)
Go multi-organism process (go_0051704)
Go response to other organism (go_0051707)
Go regulation of calcium ion transport (go_0051924)
Go dynein light intermediate chain binding (go_0051959)
Go oxidation-reduction process (go_0055114)
Go transmembrane transport (go_0055085)
Go regulation of plasma membrane bounded cell projection organization (go_0120035)
Go nucleobase-containing small molecule metabolic process (go_0055086)
Go cell chemotaxis (go_0060326)
Go regulation of cellular localization (go_0060341)
Go epithelium development (go_0060429)
Go nucleoside-triphosphatase regulator activity (go_0060589)
Go regulation of vesicle-mediated transport (go_0060627)
Go membrane organization (go_0061024)
Go process utilizing autophagic mechanism (go_0061919)
Go collagen-containing extracellular matrix (go_0062023)
Go intracellular organelle lumen (go_0070013)
Go large ribosomal subunit rrna binding (go_0070180)
Go regulation of establishment of protein localization (go_0070201)
Go regulation of erk1 and erk2 cascade (go_0070372)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go positive regulation of erk1 and erk2 cascade (go_0070374)
Go exocytic vesicle (go_0070382)
Go respirasome (go_0070469)
Go protein localization to mitochondrion (go_0070585)
Go regulation of leukocyte proliferation (go_0070663)
Go positive regulation of leukocyte proliferation (go_0070665)
Go cellular macromolecule localization (go_0070727)
Go cellular response to biotic stimulus (go_0071216)
Go cellular response to molecule of bacterial origin (go_0071219)
Go cellular response to cytokine stimulus (go_0071345)
Go cellular response to interferon-gamma (go_0071346)
Go granulocyte chemotaxis (go_0071621)
Go ribonucleoprotein complex subunit organization (go_0071826)
Go neuropeptide receptor binding (go_0071855)
Go cellular divalent inorganic cation homeostasis (go_0072503)
Go divalent inorganic cation homeostasis (go_0072507)
Go establishment of protein localization to organelle (go_0072594)
Go establishment of protein localization to mitochondrion (go_0072655)
Go lymphocyte migration (go_0072676)
Go organophosphate biosynthetic process (go_0090407)
Go synaptic membrane (go_0097060)
Go neuron projection guidance (go_0097485)
Go myeloid leukocyte migration (go_0097529)
Go granulocyte migration (go_0097530)
Go defense response to other organism (go_0098542)
Go side of membrane (go_0098552)
Go bounding membrane of organelle (go_0098588)
Go membrane region (go_0098589)
Go cell-cell adhesion (go_0098609)
Go anion transmembrane transport (go_0098656)
Go import into cell (go_0098657)
Go cell-cell adhesion via plasma-membrane adhesion molecules (go_0098742)
Go presynapse (go_0098793)
Go postsynapse (go_0098794)
Go plasma membrane protein complex (go_0098797)
Go mitochondrial protein complex (go_0098798)
Go inner mitochondrial membrane protein complex (go_0098800)
Go respiratory chain complex (go_0098803)
Go whole membrane (go_0098805)
Go lytic vacuole membrane (go_0098852)
Go membrane microdomain (go_0098857)
Go actin-based cell projection (go_0098858)
Go cellular oxidant detoxification (go_0098869)
Go intrinsic component of presynaptic membrane (go_0098889)
Go intrinsic component of postsynaptic membrane (go_0098936)
Go glutamatergic synapse (go_0098978)
Go gaba-ergic synapse (go_0098982)
Go integral component of postsynaptic membrane (go_0099055)
Go integral component of presynaptic membrane (go_0099056)
Go regulation of trans-synaptic signaling (go_0099177)
Go intrinsic component of synaptic membrane (go_0099240)
Go secretory vesicle (go_0099503)
Go cytoplasmic region (go_0099568)
Go postsynaptic specialization (go_0099572)
Go integral component of synaptic membrane (go_0099699)
Go regulation of tumor necrosis factor superfamily cytokine production (go_1903555)
Go plasma membrane bounded cell projection organization (go_0120036)
Go plasma membrane bounded cell projection morphogenesis (go_0120039)
Go catalytic activity, acting on a trna (go_0140101)
Go carbohydrate derivative metabolic process (go_1901135)
Go carbohydrate derivative catabolic process (go_1901136)
Go carbohydrate derivative biosynthetic process (go_1901137)
Go regulation of neuron death (go_1901214)
Go organic cyclic compound biosynthetic process (go_1901362)
Go organonitrogen compound catabolic process (go_1901565)
Go organonitrogen compound biosynthetic process (go_1901566)
Go organic hydroxy compound metabolic process (go_1901615)
Go organic hydroxy compound biosynthetic process (go_1901617)
Go cellular response to oxygen-containing compound (go_1901701)
Go regulation of leukocyte differentiation (go_1902105)
Go transmembrane transporter complex (go_1902495)
Go negative regulation of intracellular signal transduction (go_1902532)
Go positive regulation of intracellular signal transduction (go_1902533)
Go secondary alcohol metabolic process (go_1902652)
Go secondary alcohol biosynthetic process (go_1902653)
Go regulation of leukocyte cell-cell adhesion (go_1903037)
Go liposaccharide metabolic process (go_1903509)
Go regulation of secretion by cell (go_1903530)
Go positive regulation of secretion by cell (go_1903532)
Go positive regulation of tumor necrosis factor superfamily cytokine production (go_1903557)
Go regulation of hemopoiesis (go_1903706)
Go positive regulation of hemopoiesis (go_1903708)
Go organic acid transmembrane transport (go_1903825)
Go regulation of cation transmembrane transport (go_1904062)
Go carboxylic acid transmembrane transport (go_1905039)
Go peptidase complex (go_1905368)
Go endopeptidase complex (go_1905369)
Go oxidoreductase complex (go_1990204)
Go transferase complex (go_1990234)
Go neutrophil migration (go_1990266)
Go transporter complex (go_1990351)
Go sequence-specific double-stranded dna binding (go_1990837)
Go ribonucleoprotein complex (go_1990904)
Go regulation of cell motility (go_2000145)
Go positive regulation of cell motility (go_2000147)
Go regulation of apoptotic signaling pathway (go_2001233)
Go regulation of cation channel activity (go_2001257)
mean genset / Marioni GWAS genes
GWAS (Marioni et al.) AD Marioni p < 0.0001
GWAS (Marioni et al.) AD Marioni p < 0.0005
GWAS (Marioni et al.) AD Marioni p < 0.001
GWAS (Marioni et al.) AD Marioni p < 0.005
GWAS (Marioni et al.) AD Marioni p < 0.01
GWAS (Marioni et al.) AD Marioni p < 0.05
GWAS (Marioni et al.) AD Marioni p < 1e-05
GWAS (Marioni et al.) AD Marioni p < 1e-06
GWAS (Marioni et al.) AD Marioni p < 5e-05
GWAS (Marioni et al.) AD Marioni p < 5e-06
mean genset / Zeisel 2015 celltypes
Celltype A1
Celltype A2
Celltype DAM
Celltype Zeisel Astrocyte
Celltype Zeisel CA1 Pyramidal
Celltype Zeisel Endothelial
Celltype Zeisel Ependymal
Celltype Zeisel Interneuron
Celltype Zeisel Microglia
Celltype Zeisel Mural
Celltype Zeisel Oligodendrocyte
Celltype Zeisel Pyramidal
Celltype Zeisel S1 Pyramidal
IHC score
Abeta
Gfap
Dapi
Neun
Abeta 200
Gfap 200
Dapi 200
Neun 200
Metadata
Age
Genotype
Group
Color log1p(score)
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Wildtype
APP NLGF
Wildtype, Age 18 months
Wildtype, Age 12 months
Wildtype, Age 6 months
Wildtype, Age 3 months
APP NLGF Age 18 months
APP NLGF Age 12 months
APP NLGF Age 6 months
APP NLGF Age 3 months
Age 3 months
Age 6 months
Age 12 months
Age 18 months
Region Annotation
Region/level 1
Region/level 2
Region/level 3
Region/fine
Region/equalsize
Whole brain
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